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Parijat Bhatnagar, Ph.D.'s Resume

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ParijatBhatnagar_CareerStatementCV4Publications.pdf (1.1 MB, application/pdf): attached by Parijat (Parijat Bhatnagar, Ph.D.) on 2011-08-30 12:30; This file contains Career Statement, Curriculum Vitae, and 4 BioMEMS Publications

Contact	MD Anderson Cancer Center The Methodist Hospital Research Ins Houston, TX 77054 US 845-401-3427 [email protected]	Goal	An interdisciplinary position in BioMEMS, microfludics, cell & gene therapy benefiting from my experience in semiconductor industry and biotechnology
Contact		Skills	Photolithography, self-assembly, RIE, electroplating, surfactants, surface polymerization, mammalian cell culture, cell & gene therapy
Qualifications	PARIJAT BHATNAGAR, PhD Biomedical Engineering Cell: (845) 401 3427 [email protected] SUMMARY I am looking for a collaborative position capitalizing on my basic training in Materials Science, Microfabrication, Molecular Self-Assembly, Biomaterials, & Immunotherapy and interfacing it with Molecular & Cellular Biology. With my interdisciplinary skills in materials science and translational research, I feel passionate about a career which challenges me to grow in new areas, benefits from my strengths, creativity and diversity of experience allowing me to explore new applications in medical devices, lab-on-the-chip, microfluidics, and biosensors. In my joint research position at MD Anderson Cancer Center and The Methodist Hospital Research Institute, my focus is on utilizing nanotechnology, microfluidics, positron emission tomography and magnetic resonance imaging with cell and gene therapy to develop solutions for imaging of therapeutic T-cells in human oncology trials. With my creativity and interdisciplinary expertise I feel passionate about developing the field of nanomedicine in translational research to directly impact patient care. I bring a unique perspective and statistical knowledge from research and manufacturing in semiconductor industry, which makes me a strong candidate for translation of technologies from laboratories to clinical trials leading to commercialization. My experience in occupational relationships and building successful industry-academia partnership are recent evidence of my leadership qualities. EDUCATION Ph.D. Dept. of Biomedical Engineering Cornell University, Ithaca, NY 2007 - Thesis: Micropatterned multiplexed biofunctionalized surfaces by integrated microfabrication. M.S. Dept. of Metallurgical Engineering, University of Utah, Salt Lake City, UT 2001 - Thesis: Electrodeposition of Zn-Ni alloy coatings outside conventional electroplating baths. B.S. Dept. of Metallurgical Engineering, National Institute of Technology Warangal (NITW) 1997 - Project: Study of breakouts in continuous casting machines in Vishakapatnam Steel Plant. SKILLS BioMEMS/lab-on-a-chip: biomaterial/hydrogel, protein/DNA/nanostructure functionalization, surface polymerization/organic transformations, molecular self-assembly, microfluidics, surfactants/colloids, fluorescence microscopy Microfabrication: CAD (L-Edit), photolithography & photochemistry, deep reactive ion etching (RIE), thin-film deposition: plasma vapor deposition (PVD), chemical vapor deposition (CVD), electroplating & electrochemistry, vacuum & wet processes, SEM, AFM, statistical methods (JMP) Gene Therapy: mammalian cell culture, genetic engineering, polymerase chain reaction (PCR) amplification, restriction endonuclease, DNA ligations, DNA harvesting, bacterial cloning, site-directed mutagenesis, electroporation CITIZENSHIP: USA. ADVISORY ROLES Intel Research (Jan 2009 - current): Self-assembly processes for BioMEMS and Organic Photovoltaics. ScientiaAdvisors (May 2009): Processes and materials challenges for diagnostics/assay companies in bringing BioMEMS/Microfluidics based products from research to manufacturing. Johnson Graduate School of Management, Cornell University (Jan 2006): Role of nanotechnology (nanostructured materials) to reduce automobile manufacturing cost. This was performed for Prof. Wesley Sine and was instrumental in attracting the interest of Mr. Ratan Tata (Chairman, Tata Sons Ltd., India) for producing $2500 automobile for Indian market. WORK MD Anderson Cancer Center, Dept of Pediatrics, Houston, TX The Methodist Hospital Research Institute, Dept of Radiology, Houston, TX 2010 - current Research Engineer / Visiting Scientist BioMEMS, Nanomedicine, Cell Therapy, Nuclear Imaging Image Guided Adoptive Cell Therapy – In this post-doctoral training position I am developing cell/gene therapy for conditional expression of immunoreceptors to manufacture tumor specific T cells and packaging nanoparticles inside these cells for PET/MRI imaging and to deliver a cytolytic payload to the tumor microenvironment. A major emphasis is on translation to clinical application and thus T cells are modified using approaches that can be undertaken in compliance with current good manufacturing practice (cGMP) for Phase I/II trials. I initiated and developed a partnership with IBM Research to modify electronic nanomaterials for use as PET/MRI multi-modal imaging agents in cell therapy and have significant experience in writing successful interdisciplinary grants geared for translational goals. - Magnetic and Plasmonic nanoparticles in T Cells: Developing new methods (chemical and biochemical) to transfect T cells with nanoparticles to be used as contrast agents for in vivo imaging and tracking of transplanted therapeutic cells. - BioMEMS based microelectroporation device for increased cell transfection efficiency: Microfluidics principles are utilized for development of disposable device to electro-transfer material into T cells with increased efficiency and low cell death. Intel Corp., Hillsboro, OR 2007 - current Senior Engineer (Process Dev.) Hard Mask Etch (HME) Group, Portland Technology Development - Back End (22 nm transistor node) – Process, tools and infrastructure development for integrated metal and dielectric etch. Extensive use of Six-Sigma Methodology and Statistical Process Control (SPC) is employed for white papers implementation and process qualification. Final goal is to transfer robust next-gen module to worldwide Intel factories per Moore's Law. - Research Initiatives - Took initiative beyond my current responsibilities and conceptualized BioMEMS applications and consulted for Organic Photovoltaic Cells, Extreme Ultraviolet Lithography. Cornell University, Ithaca, NY 2003 - 2007 Graduate Research Assistant Nanobiotechnology, Biomaterials & Bioinstrumentation Dept. of Biomedical Engineering - Integrated Bioinstrumentation – Using bottom-up assembly of nanomaterials, polymers, and molecular materials with conventional top-down patterning approaches I developed high yield microfabrication processes for wafer-level multiple protein patterning and their interaction with adult stem cells. Applications in biosensors, lab-on-a-chip, and cell biology tools were developed. Experienced user of Cornell NanoScale Science & Technology Facility (CNF) and Nanobiotechnology Center (NBTC). Guided and developed equipment and chemical vendors. Self-starter of following collaborations: o Organic electronics – Prof. George Malliaras, Materials Science & Engineering. o Nanophotonics – Prof. Michal Lipson, Electrical & Computer Engineering. o Bone-cartilage tissue engineering – Prof. Alan Nixon, Large Animal Surgery, Vet. College. - Consulting: Role of nanotechnology (nanostructured materials) to reduce cost of automobile manufacturing cost. This work was performed for Prof. Wesley Sine, Johnson Graduate School of Management, in Jan 2006 and was instrumental in attracting the interest of Mr. Ratan Tata (Chairman, Tata Sons Ltd., India) for producing $2500 automobile for Indian market. IBM Microelectronics, Hopewell Junction, NY 2001 - 2002 Staff Engineer Reactive Ion Etch Development Group, Semiconductor Research & Development Center - Logic FEOL – Developed 1:6 aspect ratio non-SO2 and CH3F integrated contact etch for organic layer and BPSG 100 nm dimensions using 193 nm bilayer photoresist saving $12.0 million per year per tool. - MRAM – Process owner for dielectric etch in trench and via layers (M1/V1, M2/V2). IBM TJ Watson Research Center, Yorktown Heights, NY 2000 Process Engineer Electrochemical Laboratory, Magnetoelectronics Group - MRAM – Developed integrated wet & dry etch process for 50 Å magnetic film selective to 10 Å barrier film. University of Utah, Salt Lake City, UT 1998 - 2000 Graduate Research Assistant Surfaces & Coatings, Dept. of Metallurgical Engineering - Selective Electroplating – Developed portable equipment by introducing innovative design. Metallurgical Industry & Color Picture Tube Industry 1995 - 1998 - Samtel Color Ltd., India (Color Picture Tube Industry): Revised and maintained module specifications in compliance to ISO 9001. In-line visual defect analysis of photolithographically patterned screen coating in color picture tube. Designed and developed single implosion protection device for four products, simplifying the handling process by 75% and saving $137,000 per year on material cost. (1997 - 1998) - Star Wire (India) Ltd. (Mini Steel Plant): Developed production planning and control systems for electric arc furnace, induction furnace, rolling mills, heat treatment, foundry, and quality control impacting the production of $2.0 million per year. (1998) - Visakhapatnam Steel Plant, India (Integrated Steel Plant): Developed training guide for incoming engineers in continuous casting metal breakout causes. (6 months intern, 1996) - Uttar Pradesh Steels, India (Mini Steel Plant): Electric arc furnace steel making (7 wks intern, 1996) - ISGEC (Large Pressure Vessels): Welding (9 weeks); Foundry (4 wks intern - 1995) PROFESSIONAL DEVELOPMENT TRAINING - MD Anderson Cancer Center, 2011: Conflict theory & management - Intel Corp., 2007-08: Statistical process control, Design of experiments - Johnson Graduate School of Management, Cornell University, 2006: Innovation & technology - IBM Microelectronics, 2001: Fundamentals and principles of plasma processes - Samtel Color Ltd, 1997: Personal and inter-personal skills, Statistical process & quality control AWARDS 2011 – NSF Fellowship – “Cancer Nanotechnology: analysis, imaging and treatment over multiple scales” (Jun 7-9), Houston, TX. 2003 - 2004 – Cornell NanoBiotechnology Center Fellow. 2002 – Achieved IBM First Invention Plateau. 1997 – Second Best All-rounder Student – among 1500 graduating students of RECW, India. 1995 – Most Innovative Idea – national level at Indian Institute of Technology (IIT), Kanpur, India. 1995 – Gold Medal – national level at Institution of Engineers (India). RESEARCH GRANTS Oct 2011 - Sep 2013 – Center for Transport OncoPhysics; Physical Science-Oncology Centers - Title: Enhancing anti-cancer immunotherapy by combining Gene Research and Nano-Technology (Co-PI) PAST/PRESENT AFFILIATIONS American Association of Cancer Research, Biomedical Engineering Society, Materials Research Society, Electrochemical Society. OTHER INTERESTS Bonsai, Outdoors, Cooking. PATENTS & DISCLOSURES 11 counts in the area of Gene Therapy, Imaging, BioMEMS, EUV Photolithography, Electroplating, Reactive Ion Etch. PUBLICATIONS & CONFERENCES 16 counts, available upon request.

Updated: 2012-01-28

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